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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
AP2A1
All Species:
39.39
Human Site:
Y418
Identified Species:
78.79
UniProt:
O95782
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O95782
NP_570603.2
977
107546
Y418
R
Y
L
E
T
A
D
Y
A
I
R
E
E
I
V
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001115458
977
107553
Y418
R
Y
L
E
T
A
D
Y
A
I
R
E
E
I
V
Dog
Lupus familis
XP_541490
922
101289
S399
R
I
A
G
D
Y
V
S
E
E
V
W
Y
R
V
Cat
Felis silvestris
Mouse
Mus musculus
P17426
977
107646
Y418
R
Y
L
E
T
A
D
Y
A
I
R
E
E
I
V
Rat
Rattus norvegicus
P18484
938
104026
Y417
S
Y
L
E
T
A
D
Y
S
I
R
E
E
I
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001012914
938
104174
Y417
N
Y
L
E
T
A
D
Y
S
I
R
E
E
I
V
Frog
Xenopus laevis
NP_001089303
939
104392
Y418
S
Y
L
E
T
A
D
Y
S
I
R
E
E
I
V
Zebra Danio
Brachydanio rerio
XP_001922441
959
106027
Y418
S
Y
L
E
T
A
D
Y
S
I
R
E
E
M
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P91926
940
105602
Y418
N
Y
L
E
T
A
D
Y
S
I
R
E
E
M
V
Honey Bee
Apis mellifera
XP_394621
937
104937
Y418
N
Y
L
E
T
A
D
Y
S
I
R
E
E
M
V
Nematode Worm
Caenorhab. elegans
NP_509572
925
104161
Y417
A
Y
L
E
T
A
D
Y
S
I
R
E
E
M
V
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P38065
1025
114993
N474
Q
Y
I
L
S
P
K
N
L
A
E
P
Q
I
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
99.5
91.3
N.A.
98.4
79.4
N.A.
N.A.
79.5
78.3
82.1
N.A.
66.6
68
62.2
N.A.
Protein Similarity:
100
N.A.
99.8
92.7
N.A.
98.8
86.9
N.A.
N.A.
87.4
87
88.1
N.A.
77.8
78.8
74.9
N.A.
P-Site Identity:
100
N.A.
100
13.3
N.A.
100
86.6
N.A.
N.A.
86.6
86.6
80
N.A.
80
80
80
N.A.
P-Site Similarity:
100
N.A.
100
13.3
N.A.
100
93.3
N.A.
N.A.
93.3
93.3
93.3
N.A.
93.3
93.3
93.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
23.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
44.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
9
0
0
84
0
0
25
9
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
9
0
84
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
84
0
0
0
0
9
9
9
84
84
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
9
9
0
0
0
0
0
0
84
0
0
0
59
0
% I
% Lys:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
9
% K
% Leu:
0
0
84
9
0
0
0
0
9
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
34
0
% M
% Asn:
25
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
9
0
0
0
0
0
9
0
0
0
% P
% Gln:
9
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% Q
% Arg:
34
0
0
0
0
0
0
0
0
0
84
0
0
9
0
% R
% Ser:
25
0
0
0
9
0
0
9
59
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
84
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
9
0
0
0
9
0
0
0
92
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% W
% Tyr:
0
92
0
0
0
9
0
84
0
0
0
0
9
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _